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Return to Knowledge Base Search. Return to TOP. All Rights Reserved. Hyman said the next step is encouraging and incentivizing its Facebook Connect users to share more music on Facebook and get more Facebook friends to give MOG a try. We may collect cookies and other personal information from your interaction with our website. For more information on the categories of personal information we collect and the purposes we use them for, please view our Notice at Collection.
Become a Member Sign In. General Newsletters Got a news tip? It is a minor compound of the myelin sheath but its localization on the outer surface made it accessible to reactive antibodies. It is belived that its extracellular domain induces cellular and humoral autoimmunity 5 5. The spectrum of MOG autoantibody-associated demyelinating diseases. Nat Rev Neurol. Although, it is not clear if the variable phenotypes that have been linked to MOG-IgG are a result of the technical limitations and lack of a standard detection method 5 5.
Advanced techniques of molecular biology using cell- based assays are more sensitive and specific than those using enzyme-linked immunosorbent assays -ELISA - with linear peptides or western blot using denatured protein.
The cell-based assay method is based on transfection of live human cells with human DNA to generate expression of the MOG on the plasmatic membrane. Autoantibodies directed to conformational epitopes are then detected in the patient's sera. The cell-based assay has allowed better characterization of the clinical, radiological and laboratorial profiles of positive patients and the prognostic value of MOG-IgG.
Also, it has helped investigate its potential pathogenic effects. Previous studies in MOG-IgG positive AQP4-Ab negative NMOSD patients have suggested different clinical characteristics when compared with AQP4-Ab positive patients, such as the lack of female predominance, more caudal spinal cord lesions, better recovery from the attacks and a more frequent involvement of optic nerves, with bilateral simultaneous ON 6 6. Other clinical syndromes still lack characterization due to the low number of cases and the need for confirmation in different cohorts.
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Of the remaining patients, eight fulfilled the diagnostic criteria for MS, according the McDonald criteria of 8 8. Diagnostic criteria for multiple sclerosis: revisions to the McDonald criteria. Ann Neurol. The cells were exposed to patient diluted sera and then to a secondary goat anti-human IgG Fc-specific Dy tagged antibody Thermo-Fischer, USA to avoid cross-reaction with other immunoglobulin classes.
The samples were tested at least twice for MOG-IgG at dilution and only those considered positive by two different examiners were counted as true positives. The antibody titers were determined by final double dilution. The clinical, radiological and laboratorial characteristics of the patients were collected by chart review.
All data and samples were collected after approval by the Ethics Committee of Pontifical Catholic University of Rio Grande do Sul and all patients were informed and spontaneously consented to participate in a written agreement research form. Amongst the MOG-IgG positive group, the titers ranged from to ,, with a median titer of , Median age was 47 years ranging from 20 to 63 years. One patient presented with recurrent ON; the remaining seven patients presented with a single attack. Two patients presented with a T2-hypersignal with gadolinium enhancement of the optic nerve on the orbital MRI.
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