Primary hepatic complications are rare and usually reversible. However, ibuprofen should be avoided in patients with cirrhosis because of the decrease in functional capacity of the liver and its potential effects on the pharmacokinetics of ibuprofen and the potential for hematologic and renal complications. Interestingly, although ibuprofen is eliminated by oxidative metabolism, alcoholic liver disease appears to have minimal effect on the pharmacokinetics of ibuprofen.
As NSAIDs are eliminated through the kidneys, ibuprofen should be avoided in patients with renal disease. Concomitant use of anticoagulants increases the risk of GI bleeding by six times, and should therefore be avoided. NSAIDs should be used with caution with patients who have a history of asthma, however hypersensitivity reactions most commonly are associated with patients who have severe asthma with greater medication requirements, such as dependence on corticosteroids.
Ibuprofen is not known to be a teratogen in humans. Use of low dose, intermittent ibuprofen in pregnancy is generally considered safe by the American Academy of Pediatrics as long as it is discontinued six to eight weeks before term. However, use in the third trimester of pregnancy has been cautioned against by some and as NSAIDs are used closer to term, risks to mother and child increase.
In some cases, your doctor may prescribe a higher dose of up to mg to take 4 times a day if needed. This should only happen under supervision of a doctor. If you take ibuprofen 3 times a day, leave at least 6 hours between doses. To avoid the potential short- or long-term effects of taking too much ibuprofen, do not take more than your recommended dose.
The absolute maximum daily dose for adults is mg. Do not take more than mg in a single dose. Only use the smallest dose needed to alleviate your swelling, pain, or fever. Advil, when taken at the recommended dose, does not contain any ingredients that are likely to make you sleepy. The active ingredient in Advil is ibuprofen, an NSAID non-steroidal anti-inflammatory drug that is a pain reliever and fever reducer.
Begin typing your search term above and press enter to search. Press ESC to cancel. Infants and young children can be given liquid forms and suppositories. Older children, who can chew and swallow more easily, may take the chewable or orally disintegrating tablets.
Strength and dosage vary according to age, so always check the product instructions for exact amounts. Acetaminophen and ibuprofen are available in every pharmacy.
GoodRx can give you an idea of specific prices in stores near you. The side effects of acetaminophen and ibuprofen may differ. This is because your body breaks them down differently. For example, acetaminophen is broken down and removed by the liver. Acetaminophen has a warning about liver damage it can cause that can be fatal cause death. Liver damage can happen if you take too much in a hour period. For more information, read about the dangers of acetaminophen overdose.
Ibuprofen, on the other hand, is removed from your body by your kidneys. Taking it for a long time can cause kidney damage and stomach bleeding. Using high doses of ibuprofen for longer than recommended can increase your risk of:. Acetaminophen and ibuprofen can cause dangerous interactions when you take them with certain medications.
To reduce your risk, make sure you tell your doctor about all drugs, supplements, and herbs you take. Taking either acetaminophen or ibuprofen may cause problems if you have certain health issues. Talk to your doctor before using acetaminophen or ibuprofen if you have:.
Acetaminophen and ibuprofen both treat pain, but they work slightly differently in your body. Each drug can pose different safety issues, especially if you have existing health conditions.
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