What is the difference between sense and antisense dna

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Contact Form. Cell Introduction 2. Cell Structure 3. Membrane Structure 4. Membrane Transport 5. Origin of Cells 6. Cell Division 2: Molecular Biology 1. Metabolic Molecules 2. Water 3. Protein 5. Enzymes 6. Cell Respiration 9. Photosynthesis 3: Genetics 1. Biochem Biophys Acta J Theor Biol 95 Nussinov R Doublet frequencies in evolutionarily distinct groups. Electrophoresis 12 Pradhu VV Symmetry observations in long nucleotide sequences.

Wadsworth Publishing, Belmont, California. Shepherd JCW From primeval message to present day gene. Cell 38 Tropsha A, Kizer JS, Chaiken IM Making sense of antisense: a review of experimental data and developing ideas on sense-antisense peptide recognition. J Molec Recog 5 Nucleic Acids Res 18 J Mol Evol 38 Trends Biochem Sci 15 Return to: HomePage Click Here. Return to: Bioinformatics Genomics Click Here. A correspondence between open reading frames in sense and antisense strands is expected from the hypothesis that the prototypic triplet code was of general form RNY , where R is a purine base, N is any base, and Y is a pyrimidine.

The similar codon frequencies found in sense and antisense strands can be attributed to the wide distribution of inverted repeats stem-loop potential in natural DNA sequences. Antisense Phenomena A DNA segment encoding a protein usually has a " sense " strand and a complementary " antisense " strand which acts as a template for RNA polymerase. The proposed prototypic triplet code RNY predicts a unique relationship between reading frames in sense and antisense strands of DNA.

Role for TpA Pressure in Rhodobacter? Similar Codon Frequencies in Sense and Antisense Strands Sense and antisense strands have similar codon frequencies in various organisms Alff-Steinberger , If there are palindromes in exons then there is a potential for sense and antisense proteins to have motifs in common.

Upper : Codons in duplex DNA, which has adopted cruciform configurations, are shown as arrow-headed boxes, as in Figure 1. Codons which complement each other to form the stems of stem-loops are shown within boxes. The amino acids corresponding to each codon are shown in bold lettering.

Lower : Amino acid sequence of the sense and antisense proteins derived from the above DNA sequence. Amino acids in boxes represent motifs present in both sequences. The automatic consequence of this for protein sequences has been pointed out by Ohno and Yomo , and is illustrated in Figure 3.

Some motifs present in sense strand-derived proteins will also be present on the antisense strand-derived proteins. Thus, the properties of the latter may include some of those of the former. Antisense is the non-coding DNA strand of a gene. Antisense can also refer to a method for silencing genes. To silence a target gene, a second gene is introduced that produces an mRNA complementary to that produced from the target gene.